AUTHOR=Yu Jun-Jie , Wei Wen-Ke , Zhang Yu , Cox Russell J. , He Juan , Liu Ji-Kai , Feng Tao 

TITLE=Terpenoids from Kiwi endophytic fungus Bipolaris sp. and their antibacterial activity against Pseudomonas syringae pv. actinidiae

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.990734

DOI=10.3389/fchem.2022.990734

ISSN=2296-2646

ABSTRACT=<p>A chemical investigation on the kiwi endophytic fungus <italic>Bipolaris</italic> sp. Resulted in the isolation of eight new terpenoids (<bold>1</bold>–<bold>8</bold>) and five known analogues (<bold>9</bold>–<bold>13</bold>). Compounds <bold>1</bold>–<bold>5</bold> are novel sativene sesquiterpenoids containing three additional skeletal carbons, while compounds <bold>4</bold> and <bold>5</bold> are rare dimers. Compounds <bold>6</bold>–<bold>8</bold> and <bold>13</bold> are sesterterpenoids that have been identified from this species for the first time. Compounds <bold>4</bold> and <bold>5</bold> showed antibacterial activity against kiwifruit canker pathogen <italic>Pseudomonas syringae</italic> pv. <italic>Actinidiae</italic> (Psa) with MIC values of 32 and 64 <italic>μ</italic>g/ml, respectively.</p>