AUTHOR=Lei Hui , Zou Shunmei , Lin Jiafu , Zhai Longfei , Zhang Yifeng , Fu Xiujuan , Chen Siwei , Niu Hong , Liu Feifei , Wu Chunlian , Zhang Dan 

TITLE=Antioxidant and anti-inflammatory activity of constituents isolated from Dendrobium nobile (Lindl.)

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.988459

DOI=10.3389/fchem.2022.988459

ISSN=2296-2646

ABSTRACT=<p><italic>Dendrobium nobile</italic> (Lindl.) have long been used as herbal tea and a traditional herbal medicine to treat Alzheimer’s disease (AD). In the current study, nineteen compounds (<bold>1–19</bold>), including two new vitamin E homologues (<bold>1–2</bold>), one new sesquiterpene (<bold>6</bold>), and two new dendrobines (<bold>7</bold>, <bold>8</bold>), were isolated and identified from stems of <italic>Dendrobium nobile</italic>. Their structures were elucidated on the basis of NMR, <sup>13</sup>C NMR calculation, and DP4<sup>+</sup> probability analyses. The absolute configurations of new compounds were determined by electronic circular dichroism (ECD) data analysis. Antioxidant, anti-inflammatory, and cytotoxic activities of isolated compounds were evaluated. Among them, compound <bold>2</bold> demonstrated significant antioxidant activity compared with ascorbic acid (VC), while compounds <bold>2</bold> and <bold>4</bold> also exhibited an equal effect to positive control cisplatin. This study on the biological activity of the new vitamin E homologues from <italic>Dendrobium nobile</italic> may indicate its potential application in the pharmaceutical and food industries.</p>