AUTHOR=Duan Qunpeng , Wang Fei , Lu Kui 

TITLE=Recent advances in macrocyclic arenes-based fluorescent indicator displacement assays

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.973313

DOI=10.3389/fchem.2022.973313

ISSN=2296-2646

ABSTRACT=<p>Macrocyclic arenes-based fluorescent indicator displacement assays (F-IDAs) offer a unique and innovative approach to chemosensing, taking molecular recognition in host-guest chemistry to a higher level. Because of their special architecture and versatile host–guest binding properties, macrocyclic arenes, principally calix[<italic>n</italic>]arenes and, in recent years, pillar[<italic>n</italic>]arenes, in combination with various fluorophores, are widely used in F-IDAs for the specific and selective sensing of cationic, anionic, and neutral analytes. In this paper, we review recent progress in the development of F-IDAs based on macrocyclic arenes and outline the prospects and remaining challenges relating to macrocyclic arenes-based F-IDAs.</p>