AUTHOR=Shu Yisong , Li Feifei , Han Yaotian , Wang Penglong , Gao Feng , Yan Mengmeng , Liang Miao , Ma Qiang , Zhang Yuzhong , Ding Xia , Lei Haimin TITLE=Design, synthesis and cytotoxic evaluation of novel betulonic acid-diazine derivatives as potential antitumor agents JOURNAL=Frontiers in Chemistry VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.969770 DOI=10.3389/fchem.2022.969770 ISSN=2296-2646 ABSTRACT=
With the purpose to improve antiproliferative activity, 26 new betulonic acid-diazine derivatives were designed and synthesized from betulinic acid. The anticancer activity of these semi-synthetic compounds was evaluated by MTT assay in both tumor cell lines and normal cell line. The results indicated that majority of new compounds exhibited improved antitumor activity compared with the parent compound betulonic acid. Compound