AUTHOR=Ma Chunhua , Meng Hui , He Xing , Jiang Yuqin , Yu Bing 

TITLE=Visible-Light-Promoted Transition-Metal-Free Construction of 3-Perfluoroalkylated Thioflavones

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.953978

DOI=10.3389/fchem.2022.953978

ISSN=2296-2646

ABSTRACT=<p>A visible-light-promoted transition-metal-free perfluoroalkylation/cyclization reaction was developed with 9-mesityl-10-methylacridinium perchlorate (Acr<sup>+</sup>-Mes·ClO<sub>4</sub><sup>−</sup>) as the photocatalyst, by which various perfluoroalkyl-substituted heterocycles including thioflavones, oxindoles, and quinoline-2,4(1<italic>H</italic>,3<italic>H</italic>)-diones were prepared at room temperature. Moreover, the potential of this sustainable method is demonstrated by the excellent <italic>in vitro</italic> anti-lymphoma and cervical carcinoma activity of the novel 3-perfluoroalkylated thioflavone <bold>3m</bold>.</p>