AUTHOR=Yu Chong , Nian Yin , Chen Huanhua , Liang Shuwen , Sun Mengyang , Pei Yuehu , Wang Haifeng 

TITLE=Pyranone Derivatives With Antitumor Activities, From the Endophytic Fungus Phoma sp. YN02-P-3

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.950726

DOI=10.3389/fchem.2022.950726

ISSN=2296-2646

ABSTRACT=<p>Two new pyranone derivatives phomapyrone A (2) and phomapyrone B (3), one new coumarin 11<italic>S,</italic> 13<italic>R</italic>-(+)-phomacumarin A (1), three known pyranones (4–6), together with three known amide alkaloids fuscoatramides A-C (7–9), as well as 9<italic>S,</italic> 11<italic>R</italic>-(+)-ascosalitoxin (10) were isolated from the endophytic fungus <italic>Phoma</italic> sp. YN02-P-3, which was isolated from the healthy leaf tissue of a Paulownia tree in Yunnan Province, China. Their structures were elucidated using extensive NMR spectroscopic and HRESIMS data and by comparing the information with literature data. In addition, all compounds were tested for their cytotoxicity activity against human tumor cell lines, and the results showed that new compounds 1-3 showed moderate inhibitory activity against the HL-60 cell line with IC<sub>50</sub> values of 31.02, 34.62, and 27.90 <italic>μ</italic>M, respectively.</p>