AUTHOR=Luo Ling , Liu Dan , Lan Shichao , Gan Xiuhai 

TITLE=Design, Synthesis, and Biological Activity of Novel Chalcone Derivatives Containing an 1,2,4-Oxadiazole Moiety

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.943062

DOI=10.3389/fchem.2022.943062

ISSN=2296-2646

ABSTRACT=<p>To discover a lead compound for agricultural use, 34 novel chalcone derivatives containing an 1,2,4-oxadiazole moiety were designed and synthesized. Their nematocidal activities against <italic>Bursaphelenchus xylophilus</italic>, <italic>Aphelenchoides besseyi</italic>, and <italic>Ditylenchus dipsaci</italic> and their antiviral activities against tobacco mosaic virus (TMV), pepper mild mottle virus (PMMoV), and tomato spotted wilt virus (TSWV) were evaluated. Biological assay results indicate that compounds <bold>A13</bold> and <bold>A14</bold> showed good nematocidal activities against <italic>B. xylophilus</italic>, <italic>A. besseyi</italic>, and <italic>D. dipsaci</italic>, with LC<sub>50</sub> values of 35.5, 44.7, and 30.2 μg/ml and 31.8, 47.4, and 36.5 μg/ml, respectively, which are better than tioxazafen, fosthiazate, and abamectin. Furthermore, compound <bold>A16</bold> demonstrated excellent protective activity against TMV, PMMoV, and TSWV, with EC<sub>50</sub> values of 210.4, 156.2, and 178.2 μg/ml, respectively, which are superior to ningnanmycin (242.6, 218.4, and 180.5 μg/ml).</p>