AUTHOR=Liu Chunyi , Fei Qiang , Pan Nianjuan , Wu Wenneng 

TITLE=Design, Synthesis, and Antifungal Activity of Novel 1,2,4-Triazolo[4,3-c]trifluoromethylpyrimidine Derivatives Bearing the Thioether Moiety

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.939644

DOI=10.3389/fchem.2022.939644

ISSN=2296-2646

ABSTRACT=<p>Crop disease caused by fungi seriously affected food security and economic development. Inspired by the utilization of fungicide containing 1,2,4-triazole and trifluoromethylpyrimidine, a novel series of 1,2,4-triazolo[4,3-<italic>c</italic>]trifluoromethylpyrimidine derivatives bearing the thioether moiety were synthesized. Meanwhile, the antifungal activities of the title compounds were evaluated and most compounds exhibited obvious antifungal activities against cucumber <italic>Botrytis cinerea</italic>, strawberry <italic>Botrytis cinerea</italic>, tobacco <italic>Botrytis cinerea</italic>, blueberry <italic>Botrytis cinerea</italic>, <italic>Phytophthora infestans</italic>, and <italic>Pyricularia oryzae</italic> Cav. Among the compounds, 4, 5h, 5o, and 5r showed significant antifungal activities against three of the four <italic>Botrytis cinerea</italic>, which indicated the potential to become the leading structures or candidates for resistance to <italic>Botrytis cinerea</italic>.</p>