AUTHOR=Ke Li-Na , Kong Ling-Qi , Xu Huan-Huan , Chen Qin-Hua , Dong Yun , Li Bin , Zeng Xiao-Hua , Wang Hong-Mei 

TITLE=Research Progress on Structure and Anti-Gynecological Malignant Tumor of Shikonin

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.935894

DOI=10.3389/fchem.2022.935894

ISSN=2296-2646

ABSTRACT=<p>Gynecological malignancy seriously threatens the physical and mental health of women. Shikonin is a naphthoquinone compound with a variety of biological activities. Studies have shown that shikonin can inhibit cell proliferation, promote cell apoptosis and induce cell necrosis. And in recent years, shikonin are also being increasingly used for the study of gynecological malignant diseases. Therefore, we reviewed the mechanism of action and structure optimization of shikonin in gynecological malignant tumors, in order to provide some reference for further research and development of related drug.</p>