AUTHOR=Michalski Radosław , Smulik-Izydorczyk Renata , Pięta Jakub , Rola Monika , Artelska Angelika , Pierzchała Karolina , Zielonka Jacek , Kalyanaraman Balaraman , Sikora Adam Bartłomiej 

TITLE=The Chemistry of HNO: Mechanisms and Reaction Kinetics

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.930657

DOI=10.3389/fchem.2022.930657

ISSN=2296-2646

ABSTRACT=<p>Azanone (HNO, also known as nitroxyl) is the protonated form of the product of one-electron reduction of nitric oxide (<sup>•</sup>NO), and an elusive electrophilic reactive nitrogen species of increasing pharmacological significance. Over the past 20 years, the interest in the biological chemistry of HNO has increased significantly due to the numerous beneficial pharmacological effects of its donors. Increased availability of various HNO donors was accompanied by great progress in the understanding of HNO chemistry and chemical biology. This review is focused on the chemistry of HNO, with emphasis on reaction kinetics and mechanisms in aqueous solutions.</p>