AUTHOR=Pan Nianjuan , Liu Chunyi , Wu Ruirui , Fei Qiang , Wu Wenneng 

TITLE=Novel Pyrimidine Derivatives Bearing a 1,3,4-Thiadiazole Skeleton: Design, Synthesis, and Antifungal Activity

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.922813

DOI=10.3389/fchem.2022.922813

ISSN=2296-2646

ABSTRACT=<p>In this study, twenty novel pyrimidine derivatives bearing a 1,3,4-thiadiazole skeleton were designed and synthesized. Then their antifungal activity against <italic>Botrytis cinereal</italic> (<italic>B. cinereal</italic>), <italic>Botryosphaeria dothidea</italic> (<italic>B. dothidea</italic>), and <italic>Phomopsis</italic> sp. were determined using the poison plate technique. Biological test results showed that compound <bold>6h</bold> revealed lower EC<sub>50</sub> values (25.9 and 50.8 μg/ml) on <italic>Phompsis</italic> sp. than those of pyrimethanil (32.1 and 62.8 μg/ml).</p>