AUTHOR=Li Jia , Li Yu-An , Wu Ge , Zhang Xu 

TITLE=Metal-Free Aminohalogenation of Quinones With Alkylamines and NXS at Room Temperature

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.917371

DOI=10.3389/fchem.2022.917371

ISSN=2296-2646

ABSTRACT=<p>A simple and practical strategy for intermolecular aminohalogenation of quinone with alkyl amines and NXS was developed, in which haloamines generated <italic>in situ</italic> were employed as bifunctional reagents. The reaction system is reliable, efficient and wide in substrate range, which is suitable for the two-fold aminochlorination of 1, 4-benzoquinones, large-scale reaction and late-stage modification of pharmaceuticals.</p>