AUTHOR=Luo Huai-Zhi , Jiang Huan , Huang Xi-Shan , Jia Ai-Qun 

TITLE=New Sesquiterpenoids From Plant-Associated Irpex lacteus

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.905108

DOI=10.3389/fchem.2022.905108

ISSN=2296-2646

ABSTRACT=<p>Bacteria produce a large number of virulence factors through the quorum sensing (QS) mechanism. Inhibiting such QS system of the pathogens without disturbing their growth is a potential strategy to control multi-drug-resistant pathogens. To accomplish this, two new tremulane-type sesquiterpenoids, irpexolaceus H (<bold>1</bold>) and I (<bold>2</bold>), along with two known furan compounds, irpexlacte B (<bold>3</bold>) and C (<bold>4</bold>), were isolated from <italic>Orychophragmus violaceus</italic> (L.) OE Schulz endophytic fungus <italic>Irpex lacteus</italic> (Fr.) Fr. Their structures were elucidated by detailed spectroscopic data (NMR, HRESIMS, IR, and UV), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) analysis. Furthermore, those compounds were evaluated for anti-quorum sensing (anti-QS) activity, and compound <bold>3</bold> was found contributing to the potential QS inhibitory activity.</p>