AUTHOR=Lu Xin-Yang , Li Jing , Kong Fen-Ying , Wei Mei-Jie , Zhang Pei , Li Ying , Fang Hai-Lin , Wang Wei 

TITLE=Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO–TiO2–Au Nanocomposite-Modified Electrode

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.892919

DOI=10.3389/fchem.2022.892919

ISSN=2296-2646

ABSTRACT=<p>An electrochemical sensor for sensitive sensing of acyclovir (ACV) was designed by using the reduced graphene oxide–TiO<sub>2</sub>–Au nanocomposite-modified glassy carbon electrode (rGO–TiO<sub>2</sub>–Au/GCE). Transmission electron microscopy, X-ray diffractometer, and X-ray photoelectron spectroscopy were used to confirm morphology, structure, and composition properties of the rGO–TiO<sub>2</sub>–Au nanocomposites. Cyclic voltammetry and linear sweep voltammetry were used to demonstrate the analytical performance of the rGO–TiO<sub>2</sub>–Au/GCE for ACV. As a result, rGO–TiO<sub>2</sub>–Au/GCE exerted the best response for the oxidation of ACV under the pH of 6.0 PB solution, accumulation time of 80 s at open-circuit, and modifier amount of 7 µl. The oxidation peak currents of ACV increased linearly with its concentration in the range of 1–100 µM, and the detection limit was calculated to be 0.3 µM (S/N = 3). The determination of ACV concentrations in tablet samples also demonstrated satisfactory results.</p>