AUTHOR=Li Yitong , Chen Yu , Xie Wenli , Li Xueni , Mei Gui , Xu Jing , Zhao Xiangpei , Teng Hongli , Yang Guangzhong 

TITLE=Phenolic Compounds From the Stems and Leaves of Berchemia lineata (L.) DC

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.889441

DOI=10.3389/fchem.2022.889441

ISSN=2296-2646

ABSTRACT=<p>Eight new phenolic compounds, named bercheminols A-H (<bold>1–8</bold>), and eleven known analogues were isolated from the stems and leaves of <italic>Berchemia lineata</italic> (L.) DC. Their structures including the absolute configurations were elucidated by extensive spectroscopic analysis, chemical method, and quantum chemical calculations. Compound <bold>1</bold> possesses an unprecedented 3,4-dihydro-11H-benzo[b]pyrano[4,3-e] oxepin-11-one skeleton. The other new compounds belong to three structural types of natural products, including naphthopyrones (<bold>2–5</bold>), flavonoids (<bold>6–7</bold>), and bibenzyl (<bold>8</bold>). The <italic>α</italic>-glucosidase inhibitory activities of the isolated compounds were assayed. As a result, vittarin-B (<bold>9</bold>), rubrofusarin-6-<italic>O</italic>-<italic>β</italic>-D-glucopyranoside (<bold>11</bold>), quercetin (<bold>14</bold>), kaempferol (<bold>15</bold>), and dihydrokaempferol (<bold>17</bold>) showed moderate inhibitory activities against <italic>α</italic>-glucosidase with IC<sub>50</sub> values of 22.5, 28.0, 36.5, 32.7, and 31.9 μM, respectively.</p>