AUTHOR=Yang Min , Wu Chao , Zhang Tianxi , Shi Lei , Li Jian , Liang Hongbao , Lv Xuzhen , Jing Fengtang , Qin Lu , Zhao Tianlun , Wang Chenxi , Liu Guangxu , Feng Shuai , Li Feng TITLE=Chicoric Acid: Natural Occurrence, Chemical Synthesis, Biosynthesis, and Their Bioactive Effects JOURNAL=Frontiers in Chemistry VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.888673 DOI=10.3389/fchem.2022.888673 ISSN=2296-2646 ABSTRACT=

Chicoric acid has been widely used in food, medicine, animal husbandry, and other commercial products because of its significant pharmacological activities. However, the shortage of chicoric acid limits its further development and utilization. Currently, Echinacea purpurea (L.) Moench serves as the primary natural resource of chicoric acid, while other sources of it are poorly known. Extracting chicoric acid from plants is the most common approach. Meanwhile, chicoric acid levels vary in different plants as well as in the same plant from different areas and different medicinal parts, and different extraction methods. We comprehensively reviewed the information regarding the sources of chicoric acid from plant extracts, its chemical synthesis, biosynthesis, and bioactive effects.