AUTHOR=Qin Fu-Ying , Chen Yan-Yi , Zhang Jiao-Jiao , Cheng Yong-Xian 

TITLE=Meroterpenoid Dimers from Ganoderma Mushrooms and Their Biological Activities Against Triple Negative Breast Cancer Cells

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.888371

DOI=10.3389/fchem.2022.888371

ISSN=2296-2646

ABSTRACT=<p>(±)-Dimercochlearlactones A−J (<bold>1</bold>–<bold>10</bold>), ten pairs of novel meroterpenoid dimers and one known spirocochlealactone A (<bold>11</bold>), were isolated from <italic>Ganoderma</italic> mushrooms. The structural elucidation of new compounds, including their absolute configurations, depends on spectroscopic analysis and electronic circular dichroism (ECD) calculations. Biological studies showed that (+)- and (–)-<bold>2</bold>, (–)-<bold>3</bold>, and (+)- and (–)-<bold>11</bold> are cytotoxic toward human triple negative breast cancer (TNBC) cells (MDA-MB-231) with IC<sub>50</sub> values of 28.18, 25.65, 11.16, 8.18, and 13.02 μM, respectively. Wound healing assay revealed that five pairs of meroterpenoids (±)-<bold>5</bold>−(±)-<bold>8</bold> and (±)-<bold>10</bold> could significantly inhibit cell mobility at 20 μM in MDA-MB-231 cells. The results provide a new insight into the biological role of <italic>Ganoderma</italic> meroterpenoids in TNBC.</p>