AUTHOR=Shi Zhiyuan , Zheng Jianzhong , Tang Wenbin , Bai Yang , Zhang Lei , Xuan Zuodong , Sun Huimin , Shao Chen TITLE=Multifunctional Nanomaterials for Ferroptotic Cancer Therapy JOURNAL=Frontiers in Chemistry VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.868630 DOI=10.3389/fchem.2022.868630 ISSN=2296-2646 ABSTRACT=

Patient outcomes from the current clinical cancer therapy remain still far from satisfactory. However, in recent years, several biomedical discoveries and nanotechnological innovations have been made, so there is an impetus to combine these with conventional treatments to improve patient experience and disease prognosis. Ferroptosis, a term first coined in 2012, is an iron-dependent regulated cell death (RCD) based on the production of reactive oxygen species (ROS) and the consequent oxidization of polyunsaturated fatty acids (PUFAs). Many nanomaterials that can induce ferroptosis have been explored for applications in cancer therapy. In this review, we summarize the recent developments in ferroptosis-based nanomaterials for cancer therapy and discuss the future of ferroptosis, nanomedicine, and cancer therapy.