AUTHOR=Chen Mantao , Hu Chi , Zhang Shengxiang , Wu Dan , Mao Zhengwei , Zheng Xiujue 

TITLE=The Construction of Cucurbit[7]uril-Based Supramolecular Nanomedicine for Glioma Therapy

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.867815

DOI=10.3389/fchem.2022.867815

ISSN=2296-2646

ABSTRACT=<p>Two supramolecular nanomedicines (CB[7]⊃DOX and CB[7]⊃CPT) based on the host–guest recognition between CB[7] and anticancer drugs were constructed. After supramolecular modification, the stability and water solubility of DOX and CPT were greatly improved, and the anticancer activities of chemotherapeutic drugs were effectively maintained. This work provided a simple but efficient method to enrich supramolecular nanomedicines for cancer therapy.</p>