AUTHOR=Sun Xiao-Ying , Jia Li-Yi , Rong Zheng , Zhou Xin , Cao Lu-Qi , Li Ai-Hong , Guo Meng , Jin Jie , Wang Yin-Di , Huang Ling , Li Yi-Heng , He Zhong-Jing , Li Long , Ma Rui-Kang , Lv Yi-Fan , Shao Ke-Ke , Zhang Juan , Cao Hui-Ling 

TITLE=Research Advances on Matrine

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.867318

DOI=10.3389/fchem.2022.867318

ISSN=2296-2646

ABSTRACT=<p>Matrine is an alkaloid extracted from traditional Chinese herbs including <italic>Sophora flavescentis</italic>, <italic>Sophora alopecuroides</italic>, <italic>Sophora</italic> root, etc. It has the dual advantages of traditional Chinese herbs and chemotherapy drugs. It exhibits distinct benefits in preventing and improving chronic diseases such as cardiovascular disease and tumors. The review introduced recent research progresses on extraction, synthesis and derivatization of Matrine. The summary focused on the latest research advances of Matrine on anti-atherosclerosis, anti-hypertension, anti-ischemia reperfusion injury, anti-arrhythmia, anti-diabetic cardiovascular complications, anti-tumor, anti-inflammatory, anti-bacterium, anti-virus, which would provide new core structures and new insights for new drug development in related fields.</p>