AUTHOR=Li Kai , Xu Xiaoyu , Liu Wanshan , Yang Shouzhi , Huang Lin , Tang Shuai , Zhang Ziyue , Wang Yuning , Chen Fangmin , Qian Kun 

TITLE=A Copper-Based Biosensor for Dual-Mode Glucose Detection

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.861353

DOI=10.3389/fchem.2022.861353

ISSN=2296-2646

ABSTRACT=<p>Glucose is a source of energy for daily activities of the human body and is regarded as a clinical biomarker, due to the abnormal glucose level in the blood leading to many endocrine metabolic diseases. Thus, it is indispensable to develop simple, accurate, and sensitive methods for glucose detection. However, the current methods mainly depend on natural enzymes, which are unstable, hard to prepare, and expensive, limiting the extensive applications in clinics. Herein, we propose a dual-mode Cu<sub>2</sub>O nanoparticles (NPs) based biosensor for glucose analysis based on colorimetric assay and laser desorption/ionization mass spectrometry (LDI MS). Cu<sub>2</sub>O NPs exhibited excellent peroxidase-like activity and served as a matrix for LDI MS analysis, achieving visual and accurate quantitative analysis of glucose in serum. Our proposed method possesses promising application values in clinical disease diagnostics and monitoring.</p>