AUTHOR=Pan Xuling , Liu Qian , Nong Yingling 

TITLE=2-Alkylation of 3-Alkyindoles With Unactivated Alkenes

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.860764

DOI=10.3389/fchem.2022.860764

ISSN=2296-2646

ABSTRACT=<p>An acid-catalyzed 2-alkylation of indole molecules is developed. Only catalytic amount of the commercially available, inexpensive and traceless HI is used as the sole reaction promoter. 2,3-Disubstituted indole molecules bearing congested tertiary carbon centers are afforded as the final products in moderate to excellent yields.</p>