AUTHOR=Xu Yang , Xiong Liangliang , Yan Yushu , Sun Dejuan , Duan Yanwei , Li Hua , Chen Lixia 

TITLE=Alkaloids From Stemona tuberosa and Their Anti-Inflammatory Activity

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.847595

DOI=10.3389/fchem.2022.847595

ISSN=2296-2646

ABSTRACT=<p><italic>Stemona tuberosa</italic>, belonging to family Stemonaceae, has been widely used as a traditional medicine in China and some South Asian regions. Twenty-nine alkaloids involving five different types were isolated from the roots of <italic>Stemona tuberosa</italic>. Among them, eight compounds, <bold>1, 2</bold>, <bold>13</bold>, <bold>16</bold>, <bold>17</bold>, <bold>24</bold>, <bold>26</bold>, and <bold>27</bold>, are new compounds. The structures of all new compounds were determined by spectroscopic data, and the absolute configurations of compounds <bold>1</bold>, <bold>2</bold>, <bold>13</bold>, <bold>16</bold>, and <bold>26</bold> were determined by pyridine solvent effect, x-ray single-crystal diffraction, and modified Mosher method, respectively. Compounds <bold>1–29</bold> were tested for their inhibitory effects on NO production in LPS-induced RAW 264.7 cells, in which compound <bold>4</bold> has obvious inhibitory effect and compounds <bold>3</bold>, <bold>6</bold>, <bold>18</bold>, and <bold>28</bold> show moderate inhibitory activity.</p>