AUTHOR=Wang Long-Sheng , Guo Chao , Hu Da , Zhao Yan-Xi , Liu Hui-Hui , Dong Yu-Jia , Sun Shang-Bin , Liu Xing , Hu Kang-Hong , Wei Yan-Hong 

TITLE=Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.841151

DOI=10.3389/fchem.2022.841151

ISSN=2296-2646

ABSTRACT=<p>A class of iodobenzoyldiazenido-functionalized POMs (TBA)<sub>3</sub> [Mo<sub>6</sub>O<sub>18</sub>(=N=NCOAr)] (Ar = Ph-<italic>o</italic>-I <bold>(1)</bold>; Ph-<italic>m</italic>-I <bold>(2)</bold>; Ph-<italic>p</italic>-I <bold>(3)</bold>; Ph-3,4-I<sub>2</sub><bold>(4)</bold>; Ph-2,3,5-I<sub>3</sub><bold>(5)</bold> (TBA = tetrabutylammonium) were prepared <italic>via</italic> the refluxing reaction of <italic>α</italic>-octamolybdates, DCC, and corresponding hydrazides in dry acetonitrile. Their structures were determined by Fourier-transform infrared spectroscopy, ultraviolet–visible spectra, X-ray photoelectron spectroscopy, hydrogen-1 nuclear magnetic resonance, and high-resolution mass spectrometry. Research on the biological activity of title compounds shows that <bold>L3, L5</bold>, <bold>3</bold>, and <bold>5</bold> demonstrate potent inhibitory activity against coxsackievirus B3 and low <italic>in vitro</italic> cytotoxic activity against Hep-2 cell lines. The covalent linkage between the iodobenzoyldiazenido components and POMs can enhance the molecular inhibitory efficiency of iodobenzohydrazides.</p>