AUTHOR=Chen De , Lu Hao , Liu Yuxuan , Deng Wei , Qiu Renhua , Xiang Jiannan 

TITLE=One-Pot Three-Component Coupling Reaction of α-Amino Aryl Ketones, Indoles, and Perbromomethane Under Mild Conditions

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.825772

DOI=10.3389/fchem.2022.825772

ISSN=2296-2646

ABSTRACT=<p>A simple and efficient one-pot three-component cascade reaction of <italic>α-</italic>amino aryl ketones, indoles, and CBr<sub>4</sub> in moderate to good yields has been developed. This new strategy exhibits excellent mild reaction conditions and step-economy, easily accessible reactants, and simultaneous construction of three different new bonds (C=N, C–C, and N-Br) in a single step. It is worth noting that the protocol developed provides a simple and practical tool for the construction of diverse indole-containing heterocyclic frameworks, indicating its potential applications in medicinal and material chemistry.</p>