AUTHOR=Zhang Ying , Yu Yingying , Gao Jie 

TITLE=Supramolecular Nanomedicines of In-Situ Self-Assembling Peptides

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.815551

DOI=10.3389/fchem.2022.815551

ISSN=2296-2646

ABSTRACT=<p>Nanomedicines provide distinct clinical advantages over traditional monomolecular therapeutic and diagnostic agents. Supramolecular nanomedicines made from <italic>in-situ</italic> self-assembling peptides have emerged as a promising strategy in designing and fabricating nanomedicines. <italic>In-situ</italic> self-assambly (SA) allows the combination of nanomedicines approach with prodrug approach, which exhibited both advantages of these strategies while addressed the problems of both and thus receiving more and more research attention. In this review, we summarized recently designed supramolecular nanomedicines of <italic>in-situ</italic> SA peptides in the manner of applications and design principles, and the interaction between the materials and biological environments was also discussed.</p>