AUTHOR=Kumar Vineet , Goswami Pramod Kumar , Balendra  , Tewari Shailabh , Ramanan Arunachalam 

TITLE=Multicomponent Solids of Niflumic and Mefenamic Acids Based on Acid-Pyridine Synthon

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.729608

DOI=10.3389/fchem.2022.729608

ISSN=2296-2646

ABSTRACT=<p>The present study discusses comparative structural features of fourteen multicomponent solids of two non-steroidal anti-inflammatory drugs, Niflumic and Mefenamic acids, with amine and pyridine-based coformers. All the solids were structurally characterized through PXRD, SCXRD, DSC, and the monophasic nature of some of the solids was established through Rietveld refinement. The solid forms include salt, cocrystal, hydrate, and solvate. Except for two, all the solids reported here showed relatively higher solubility compared to the acids. The difference in p<italic>K</italic>a and similarity in structural features of both the molecules enabled us to study the effect of Δp<italic>K</italic>a on crystallization outcome systematically. The structures of all the solids are described through acid-pyridine synthon perspective.</p>