AUTHOR=Li Shirui , Wang Kang , Wang Zeyu , Zhang Wenjie , Liu Zenglin , Cheng Yugang , Zhu Jiankang , Zhong Mingwei , Hu Sanyuan , Zhang Yun TITLE=Application and trend of bioluminescence imaging in metabolic syndrome research JOURNAL=Frontiers in Chemistry VOLUME=10 YEAR=2023 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.1113546 DOI=10.3389/fchem.2022.1113546 ISSN=2296-2646 ABSTRACT=

Bioluminescence imaging is a non-invasive technology used to visualize physiological processes in animals and is useful for studying the dynamics of metabolic syndrome. Metabolic syndrome is a broad spectrum of diseases which are rapidly increasing in prevalence, and is closely associated with obesity, type 2 diabetes, nonalcoholic fatty liver disease, and circadian rhythm disorder. To better serve metabolic syndrome research, researchers have established a variety of animal models expressing luciferase, while also committing to finding more suitable luciferase promoters and developing more efficient luciferase-luciferin systems. In this review, we systematically summarize the applications of different models for bioluminescence imaging in the study of metabolic syndrome.