AUTHOR=Chen Tianyu , Zhao Xiaoying , Weng Yunxuan 

TITLE=Self-assembled polylactic acid (PLA): Synthesis, properties and biomedical applications

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2023

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.1107620

DOI=10.3389/fchem.2022.1107620

ISSN=2296-2646

ABSTRACT=<p>The surface morphology and topography of cell culture substrates play an important role in cell proliferation and growth. Regulation of the surface microstructure allows the development of tissue culture media suitable for different cells. Polylactic acid (PLA) is a biobased and biodegradable (under defined conditions) polymer with low immunogenicity, non-toxicity, and good mechanical properties, which have facilitated their pharmaceutical and biomedical applications. This review summarizes recent advances in the synthesis and self-assembly of surface microstructure based on PLA materials and discusses their biomedical applications such as cell culturing and tissue engineering.</p>