AUTHOR=Lian Zheng , Lu Chunqing , Zhu Jiangqi , Zhang Xining , Wu Ting , Xiong Youlin , Sun Zhiyi , Yang Rong 

TITLE=Mo@ZIF-8 nanozyme preparation and its antibacterial property evaluation

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.1093073

DOI=10.3389/fchem.2022.1093073

ISSN=2296-2646

ABSTRACT=<p>Types of nanozymes can produce free radicals and/or reactive oxygen species (ROS) to serve as broad spectrum antibacterial materials. Developing nanozyme-based antibacterial materials with good biocompatibility exhibits promising application prospects. In this study, we doped Mo to ZIF-8 (both components have good biocompatibility) to prepare a new nanozyme, Mo@ZIF-8, which can produce hydroxyl radicals (•OH) triggered by a low dosage of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), exhibiting effective antibacterial capability against both Gram-negative bacteria (<italic>Escherichia coli</italic>) and Gram-positive bacteria (<italic>Staphylococcus aureus</italic>). This work provides a reference for the design of antibacterial nanozymes with good biocompatibility.</p>