AUTHOR=Jiang Yonggang , Wang Bijun , Liu Dongxiang , Xia Dazhen , Liu Zhengfen , Li Liang , Deng Guogang , Yang Xiaodong 

TITLE=Aryl acrylonitriles synthesis enabled by palladium-catalyzed α-alkenylation of arylacetonitriles with vinyl halides/triflates

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.1091566

DOI=10.3389/fchem.2022.1091566

ISSN=2296-2646

ABSTRACT=<p>Aryl acrylonitriles are an important subclass of acrylonitriles in the medicinal chemistry and pharmaceutical industry. Herein, an efficient synthesis of aryl acrylonitrile derivatives using a Palladium/NIXANTPHOS-based catalyst system was developed. This approach furnishes a variety of substituted and functionalized aryl acrylonitriles (up to 95% yield). The scalability of the transformation and the synthetic versatility of aryl acrylonitrile were demonstrated.</p>