AUTHOR=Wang Limei , Li Zhuo , Ma Zhehan , Xia Kedi , Wang Wenyu , Yu Wenchang TITLE=Anticancer-active 3,4-diarylthiolated maleimides synthesis via three-component radical diarylthiolation JOURNAL=Frontiers in Chemistry VOLUME=10 YEAR=2022 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.1089860 DOI=10.3389/fchem.2022.1089860 ISSN=2296-2646 ABSTRACT=

Herein, we report an efficient and simple copper-catalyzed oxidative diarylthiolation of maleimides with sulfur powder and aryl boronic acids, in which S powder was used as a substrate and internal oxidant. The corresponding double C-S bonds coupling products were obtained in moderate to high yields under a simple catalytic system. Mechanistic studies indicated that copper-catalyzed radical thiolation of aryl boronic acids with S powder, and the resulting arylthiyl underwent radical addition with double bonds of maleimides.