AUTHOR=Ma Chunhua , Shang Linchun , Zhao Hanying , He Xing , Lv Qiyan , Zhang Dandan , Jiang Yuqin 

TITLE=Visible light-promoted transition metal-free direct C3-carbamoylation of 2H-Indazoles

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.1087834

DOI=10.3389/fchem.2022.1087834

ISSN=2296-2646

ABSTRACT=<p>We reported a general transition metal-free transformation to access C3-carbamoylated 2<italic>H</italic>-indazoles via visible light-induced oxidative decarboxylation coupling, in the presence of oxamic acids as the coupling sources, 4CzIPN as the photocatalyst, and Cs<sub>2</sub>CO<sub>3</sub> as the base. The great application potential of this mild condition is highlighted by the late-stage modification of drugs, N-terminal modification of peptides, and the good antitumor activity of the novel desired product.</p>