AUTHOR=Shen Zhong-Hui , Lu Si-Yuan , Zheng Jing-Yun , Zhang Xiang-Zhi , Peng Jin-Bao , Ma Ai-Jun 

TITLE=Studies toward synthesis of the core skeleton of spiroaspertrione A

JOURNAL=Frontiers in Chemistry

VOLUME=10

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2022.1022533

DOI=10.3389/fchem.2022.1022533

ISSN=2296-2646

ABSTRACT=<p>Bioassay-guided isolation of spiroaspertrione A from cultures of <italic>Aspergillus sp</italic>. TJ23 in 2017 demonstrated potent resensitization of oxacillin against methicillin-resistant <italic>Staphylococcus aureus</italic> by lowering the oxacillin minimal inhibitory concentration up to 32-fold. To construct this unique spiro[bicyclo[3.2.2]nonane-2,1′-cyclohexane] system, a protocol for ceric ammonium nitrate-induced intramolecular cross-coupling of silyl enolate is disclosed.</p>