AUTHOR=Lai Miao , Su Fangyao , Hu Jingyi , Wang Mengzhuo , Zhao Mingqin , Zhang Ganlin 

TITLE=Synthesis of N-Heteroarenemethyl Esters via C–C Bond Cleavage of Acyl Cyanides Under Transition Metal-Free Conditions

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.822625

DOI=10.3389/fchem.2021.822625

ISSN=2296-2646

ABSTRACT=<p>A practical method to synthesize <italic>N</italic>-heteroaryl esters from <italic>N</italic>-heteroaryl methanols with acyl cyanides <italic>via</italic> C–C bond cleavage without using any transition metal is demonstrated here. The use of Na<sub>2</sub>CO<sub>3</sub>/15-crown-5 couple enables access to a series of <italic>N</italic>-heteroaryl esters in high efficiency. This protocol is operationally simple and highly environmentally benign producing only cyanides as byproducts.</p>