AUTHOR=Ferreira Daniela R. , Alves Paula C. , Kirillov Alexander M. , Rijo Patrícia , André Vânia 

TITLE=Silver(I)-Tazobactam Frameworks with Improved Antimicrobial Activity

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.815827

DOI=10.3389/fchem.2021.815827

ISSN=2296-2646

ABSTRACT=<p>Tazobactam (TazoH) is a penicillinate sulfone β-lactamase inhibitor with negligible antimicrobial activity, commonly used with other antibiotics to provide an effective combination against many susceptible organisms expressing β-lactamases. Two novel Ag(I)-tazobactam frameworks ([Ag(I)-Tazo] and [Ag(I)-Tazo<sub>2</sub>]) prepared by mechanochemistry are presented herein as alternative forms to improve the antimicrobial activity of tazobactam by exploring synergistic effects with silver, being the first crystal structures reported of tazobactam coordinating to a metal site. The topological analysis of the 3D ([Ag(I)-Tazo]) and 2D+1D ([Ag(I)-Tazo<sub>2</sub>]) frameworks revealed underlying nets with the <bold>cbs</bold> (CrB self-dual) and decorated <bold>sql</bold> topologies, respectively. These novel frameworks are stable and show an enhanced antimicrobial activity when compared to tazobactam alone. Amongst the tested microorganisms, <italic>Pseudomonas aeruginosa</italic> is the most sensitive to tazobactam and the new compounds. This study thus unveils novel facets of tazobactam chemistry and opens up its application as a multifunctional linker for the design of antibiotic coordination frameworks and related materials.</p>