AUTHOR=Guo Hong-Wei , Tian Yun-Gang , Liu Yi-Han , Huang Jia , Wang Jian-Xia , Long Hua , Wei Hua 

TITLE=Discovery of Polyoxypregnane Derivatives From Aspidopterys obcordata With Their Potential Antitumor Activity

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.799911

DOI=10.3389/fchem.2021.799911

ISSN=2296-2646

ABSTRACT=<p>The bioassay-guided phytochemical study of an ethnic medicinal plant <italic>Aspidopterys obcorda</italic> ta Hemsl. var. obcordata results in the isolation of eight new polyoxypregnane derivatives, named aspidatasides A–H (1–8), along with ten known analogs (9–18). The series polyoxypregnane derivatives were screened for their cytoxic activity against HL-60 cells, and compound 2 showed the highest potency with an IC<sub>50</sub> 8.03 μM. Preliminary structure–activity relationship studies displayed that the sugar chain and double bond could notably impact their biological activity.</p>