AUTHOR=Mirzania Foroogh , Moridi Farimani Mahdi , Sarrafi Yaghoub , Nejad Ebrahimi Samad , Troppmair Jakob , Kwiatkowski Marcel , Stuppner Hermann , Alilou Mostafa 

TITLE=New Sesterterpenoids from Salvia mirzayanii Rech.f. and Esfand. Stereochemical Characterization by Computational Electronic Circular Dichroism

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.783292

DOI=10.3389/fchem.2021.783292

ISSN=2296-2646

ABSTRACT=<p>Phytochemical investigation on the acetone extract of <italic>Salvia mirzayanii</italic> Rech. f. and Esfand. afforded seven new isoprenoids including six new sesterterpenoids salvimirzacolide A-F (<bold>1–6</bold>), and one new nor-diterpenoid (<bold>7</bold>). Their structures were established by comprehensive spectroscopic and spectrometric data analysis (1D and 2D NMR, HRMS) and DP4+ NMR chemical shift probability calculation technique. Moreover, the absolute configuration of compounds was determined by using electronic circular dichroism spectroscopy. Evaluation of antiproliferative properties of compounds isolated against four human melanoma cancer cells displayed no cytotoxic activity at the concentration range used.</p>