AUTHOR=Alshabanah Latifah A. , Al-Mutabagani Laila A. , Gomha Sobhi M. , Ahmed Hoda A. 

TITLE=Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2022

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.762248

DOI=10.3389/fchem.2021.762248

ISSN=2296-2646

ABSTRACT=<p>A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds showed promising anticancer activities.</p>