AUTHOR=Teng Haida , Li Qingqing , Ma Ziyu , Li Xueni , Xie Wenli , Chen Yu , Yang Guangzhong 

TITLE=Polyprenylated Acylphloroglucinols With Different Carbon Skeletons From the Fruits of Garcinia multiflora

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.756452

DOI=10.3389/fchem.2021.756452

ISSN=2296-2646

ABSTRACT=<p>Eleven new polycyclic polyprenylated acylphloroglucinols (PPAPs, <bold>1</bold>–<bold>11</bold>) and three new monocyclic polyprenylated acylphloroglucinols (MPAPs, <bold>12</bold>–<bold>14</bold>), together with ten known analogues were isolated from the fruits of <italic>Garcinia multiflora</italic>. These PPAPs belong to three types including the bicyclic polyprenylated acylphloroglucinols (BPAPs), the caged PPAPs, and the complicated PPAPs. Their structures and absolute configurations were determined through HRESIMS, NMR spectroscopy data, electronic circular dichroism (ECD) calculations, and gauge-independent atomic orbital (GIAO) NMR calculations with DP4+ analyses. Moreover, compounds <bold>2</bold> and <bold>7</bold> exhibited moderate cytotoxicity against three human cancer lines (MCF-7, T98, and HepG2) with IC<sub>50</sub> values ranging from 9.81 ± 1.56 to 17.00 ± 2.75 μM.</p>