AUTHOR=Zhao Huan , Liu Yue , Zhang Meng , Chen Guo-dong , Hu Dan , Guo Liang-dong , Zhao Zhong-xiang , Zhi Hui , Gao Hao 

TITLE=Two New Diterpenoids from Biscogniauxia sp. and Their Activities

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.749272

DOI=10.3389/fchem.2021.749272

ISSN=2296-2646

ABSTRACT=<p>Two new diterpenoids, including a <italic>seco</italic>-isopimarane type (1) and an abietane type (2), were isolated from <italic>Biscogniauxia</italic> sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, <sup>13</sup>C chemical shifts calculations, and ECD calculations. This is the first report of diterpenoids from <italic>Biscogniauxia</italic> sp. Furthermore, short-term memory enhancement against Alzheimer’s disease (AD), anti-inflammatory, and cytotoxic activities of 1–2 were also evaluated. The results showed that compound 1 exhibited short-term memory enhancement activity against AD.</p>