AUTHOR=Xing Yuhang , Qing Xueqin , Xia Hao , Hao Shiqi , Zhu Haofang , He Yiyan , Mao Hongli , Gu Zhongwei TITLE=Injectable Hydrogel Based on Modified Gelatin and Sodium Alginate for Soft-Tissue Adhesive JOURNAL=Frontiers in Chemistry VOLUME=9 YEAR=2021 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.744099 DOI=10.3389/fchem.2021.744099 ISSN=2296-2646 ABSTRACT=

To assist or replace the traditional suture techniques for wound closure, soft-tissue adhesives with excellent adhesion strength and favorable biocompatibility are of great significance in biomedical applications. In this study, an injectable hydrogel tissue adhesive containing adipic acid dihydrazide–modified gelatin (Gel-ADH) and oxidized sodium alginate (OSA) was developed. It was found that this tissue adhesive possessed a uniform structure, appropriate swelling ratio, good injectability, and excellent hemocompatibility and cytocompatibility. The adhesion capacity of the developed adhesive with optimized component and concentration was stronger than that of the commercial adhesive Porcine Fibrin Sealant Kit. All these results suggested that the developed hydrogel was a promising candidate for a soft-tissue adhesive.