AUTHOR=Lu Xiuxiang , Zhang Yanjiang , Zhang Wenge , Wang Huan , Zhang Jun , Wang Sasa , Tan Haibo TITLE=Cyclohexanone and Phenolic Acid Derivatives from Endophytic Fungus Diaporthe foeniculina JOURNAL=Frontiers in Chemistry VOLUME=Volume 9 - 2021 YEAR=2021 URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.738307 DOI=10.3389/fchem.2021.738307 ISSN=2296-2646 ABSTRACT=

Chemical investigation of an endophytic fungus Diaporthe foeniculina SCBG-15, led to the isolation of eight new cyclohexanone derivatives, foeniculins A–H (1–8) and three new phenolic acid derivatives, foeniculins I–K (9–11). Their structures were extensively established on the basis of 1H and 13C NMR spectra together with COSY, HSQC, HMBC, and NOESY experiments. The absolute configurations were confirmed by quantum chemical ECD calculations and single-crystal X-ray diffractions. Moreover, the in vitro cytotoxic and antibacterial activities of isolated compounds 1–11 were also evaluated.