AUTHOR=Yuan Chao , Guo Yuhua , Wang Ke , Wang Zhunian , Li Longfei , Zhu Huajie , Li Gang 

TITLE=A Novel Azaphilone Muyophilone A From the Endophytic Fungus Muyocopron laterale 0307-2

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.734822

DOI=10.3389/fchem.2021.734822

ISSN=2296-2646

ABSTRACT=<p>Two known azaphilone derivatives, 4,6-dimethylcurvulinic acid (<bold>1</bold>) and austdiol (<bold>2</bold>), and their novel heterotrimer, muyophilone A (<bold>3</bold>), were isolated and identified from an endophytic fungus, <italic>Muyocopron laterale</italic> 0307-2. Their structures and stereochemistry were established by extensive spectroscopic analyses including HRMS, NMR spectroscopy, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectroscopic methods, as well as single crystal X-ray diffraction. In the structure of <bold>3</bold>, two compound <bold>2</bold>-derived azaphilone units were connected through an unprecedented five-membered carbon bridge which was proposed to be originated from compound <bold>1</bold>. Compound <bold>3</bold> represents the first example of azaphilone heterotrimers.</p>