AUTHOR=Liu Zeyang , Wang Yongjie , Liu Kaihong , Wang Shanshan , Liao Haocheng , Zhu Yuanli , Hou Baoming , Tan Chunxia , Liu Guohua 

TITLE=Integrated Cobaloxime and Mesoporous Silica-Supported Ruthenium/Diamine Co-Catalysis for One-Pot Hydration/Reduction Enantioselective Sequential Reaction of Alkynes

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.732542

DOI=10.3389/fchem.2021.732542

ISSN=2296-2646

ABSTRACT=<p>This study developed a cost-efficient hydration/asymmetric transfer hydrogenation (ATH) process for the one-pot synthesis of valuable chiral alcohols from alkynes. During this process, the initial homogeneous cobaloxime-catalyzed hydration of alkynes was followed by heterogeneous Ru/diamine-catalyzed ATH transformation of the <italic>in-situ</italic> generated ketones, which provided varieties of chiral alcohols in good yields with up to 99% <italic>ee</italic> values. The immobilized Ru/diamine catalyst could be recycled at least three times before its deactivation in the sequential reaction system. This work shows a general method for developing one-pot asymmetric sequential catalysis towards sustainable organic synthesis.</p>