AUTHOR=Wang Cong , Sarotti Ariel M. , Zaman KH Ahammad Uz , Wu Xiaohua , Cao Shugeng 

TITLE=New Alkaloids From a Hawaiian Fungal Strain Aspergillus felis FM324

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.724617

DOI=10.3389/fchem.2021.724617

ISSN=2296-2646

ABSTRACT=<p>Two new alkaloids tryptoquivaline Y (1) and pseurotin I (2), together with eight known compounds (3–10), were purified from a fungal strain <italic>Aspergillus felis</italic> FM324, which was isolated from a Hawaiian beach soil sample. The absolute configuration and physicochemical data of tryptoquivaline Z (3) were reported for the first time here in this paper. Compound 1 is an uncommon tryptoquivaline analog containing a 3-<italic>O</italic>-isobutanoyl group. The structures of the new compounds 1–2 and known compound 3 were elucidated through HRESIMS, NMR spectroscopy and ECD analysis. All the compounds were evaluated for their antiproliferative, antibacterial and NF-κB inhibitory activities. Compound 4 showed weak antibacterial activity against <italic>Staphylococcus aureus</italic>, methicillin resistant <italic>Staphylococcus aureus</italic> and <italic>Bacillus subtilis</italic> with the same MIC value of 59.2 µM. Compounds <bold>3</bold> and <bold>2</bold> inhibited NF-κB with IC<sub>50</sub> values of 26.7 and 30.9 μM, respectively.</p>