AUTHOR=Yu Ronglu , Liu Jia , Wang Yi , Wang Hong , Zhang Huawei 

TITLE=Aspergillus niger as a Secondary Metabolite Factory

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.701022

DOI=10.3389/fchem.2021.701022

ISSN=2296-2646

ABSTRACT=<p><italic>Aspergillus niger</italic>, one of the most common and important fungal species, is ubiquitous in various environments. <italic>A. niger</italic> isolates possess a large number of cryptic biosynthetic gene clusters (BGCs) and produce various biomolecules as secondary metabolites with a broad spectrum of application fields covering agriculture, food, and pharmaceutical industry. By extensive literature search, this review with a comprehensive summary on biological and chemical aspects of <italic>A. niger</italic> strains including their sources, BGCs, and secondary metabolites as well as biological properties and biosynthetic pathways is presented. Future perspectives on the discovery of more <italic>A. niger</italic>-derived functional biomolecules are also provided in this review.</p>