AUTHOR=Ming Wenzhuo , Zhang Yi , Sun Yiwei , Bi Guangming , Su Jing , Shao Zhutao , Meng Dali 

TITLE=Guaianolide Sesquiterpenes With Significant Antiproliferative Activities From the Leaves of Artemisia argyi

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.698700

DOI=10.3389/fchem.2021.698700

ISSN=2296-2646

ABSTRACT=<p>Four new guaiane-type sesquiterpenes, argyin H–K (1–4), and two known analogues (5 and 6) were isolated from the leaves of <italic>Artemisia argyi</italic> Lévl et Vant. The new compounds were characterized by the basic analysis of the spectroscopic data obtained (<sup>1</sup>H NMR, <sup>13</sup>C NMR, HMBC, and NOESY experiments), and their absolute configurations were determined by empirical approaches, combined with the exciton chirality method and electronic circular dichroism calculations. To further understand the antitumor effects of <italic>A. argyi</italic>, the antiproliferative activities of these compounds against A549, MCF-7, and HepG2 cell lines were tested <italic>in vitro</italic> using CCK-8 assays. The results showed that these compounds had significant antiproliferative effects on MCF-7, with IC<sub>50</sub> values of 15.13–18.63 μM, which were superior to that of oxaliplatin (i.e., IC<sub>50</sub> 22.20 μM).</p>