AUTHOR=Hu Meigeng , Zhao Dan , Xu Xudong , Ma Guoxu , Wu Haifeng , Chen Xi 

TITLE=Actaticas A−G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.695456

DOI=10.3389/fchem.2021.695456

ISSN=2296-2646

ABSTRACT=<p>Phytochemical studies on the rhizomes of <italic>Actaea asiatica</italic> led to the isolation of seven new cycloartane triterpenes, actaticas A−G (<bold>1−7</bold>). Their structures were determined by NMR, HRESIMS, and chemical analysis. All the isolates were evaluated for their antiproliferative activity against HT-29 and McF-7 cell lines. The results showed that all the compounds displayed cytotoxicity. All compounds showed significant inhibitory effects with IC<sub>50</sub> values of 9.2–26.4 μM.</p>