AUTHOR=Yanyan Zheng , Lin Jing , Xie Liuhong , Tang Hongliang , Wang Kailong , Liu Jiyang 

TITLE=One-Step Preparation of Nitrogen-Doped Graphene Quantum Dots With Anodic Electrochemiluminescence for Sensitive Detection of Hydrogen Peroxide and Glucose

JOURNAL=Frontiers in Chemistry

VOLUME=9

YEAR=2021

URL=https://www.frontiersin.org/journals/chemistry/articles/10.3389/fchem.2021.688358

DOI=10.3389/fchem.2021.688358

ISSN=2296-2646

ABSTRACT=<p>Simple and efficient synthesis of graphene quantum dots (GQDs) with anodic electrochemiluminescence (ECL) remains a great challenge. Herein, we present an anodic ECL-sensing platform based on nitrogen-doped GQDs (N-GQDs), which enables sensitive detection of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and glucose. N-GQDs are easily prepared using one-step molecular fusion between carbon precursor and a dopant in an alkaline hydrothermal process. The synthesis is simple, green, and has high production yield. The as-prepared N-GQDs exhibit a single graphene-layered structure, uniform size, and good crystalline. In the presence of H<sub>2</sub>O<sub>2</sub>, N-GQDs possess high anodic ECL activity owing to the functional hydrazide groups. With N-GQDs being ECL probes, sensitive detection of H<sub>2</sub>O<sub>2</sub> in the range of 0.3–100.0 μM with a limit of detection or LOD of 63 nM is achieved. As the oxidation of glucose catalyzed by glucose oxidase (GOx) produces H<sub>2</sub>O<sub>2</sub>, sensitive detection of glucose is also realized in the range of 0.7–90.0 μM (LOD of 96 nM).</p>